The Gunners team will be desperate to give their long-term manager, Arsene Wenger, who has been with the North London outfit since his appointment in 1996 and will be leaving the club at the end of the season, the best retirement in history.
During his spell at the Emirates Stadium, Wenger has yet to add an European Trophy to his list of trophies collected for the English club, which will make him more desperate to win the Europa League.
With the European cup seeming the only way to secure a spot in the Champions League next season, having dropped out of the race in the top four in the Premier League.
The North London outfit are only four games away to the end of a Premier League season placed 6th, and 11 points behind fourth sitters Tottenham Hotspur with Chelsea taking the 5th position, which has killed any dream of a top four hopes in the English Top Flight.
However, Arsenal finished 1st in the Group stage of the Europa League with four victories and a draw, which sees them extend to the round of 32, where they faced Ostersund and progressed to the round of 16 to face AC Milan and defeat the Serie A outfit.
The Gunners also got passed Russian side CSKA Moscow in an aggregate of 6-3, which got them to the semi-finals drawn with Atletico Madrid.
The North London supporters might be thinking they got the worst of draw possible.
However, here will be a predicted lineup for the Gunners tomorrow as they will be facing the two times Champions League runners up.
Predicted Lineup: David Ospina, Hector Bellerin, Shkodran Mustafi, Laurent Koscienly, Nacho Monreal, Aaron Ramsey, Granit Xhaka, Jack Wilshere, Mesut Ozil, Danny Welbeck, Alexandre Lacazette.
Henrikh Mkhitaryan might just be sitting out on this match with an injury acquired when playing against CSKA Moscow during the first leg.